Welcome to the Larrondo Lab
The Larrondo Lab is interested in different aspects of gene expression. In particular, we study the molecular mechanisms underlying biological oscillators, assessing the impact that circadian clocks have on physiology and in host-pathogen interactions. We use various fungal organisms as model systems to study these complex biological processes: the filamentous fungus Neurospora crassa, the phytopathogen Botrytis cinerea, the biocontroller Trichoderma atroviride and the yeast Saccharomyces cerevisiae.
Our studies employ functional genomics strategies, as well as the use of real-time reporters. Lately, we have began adopting optogenetics and synthetic biology approaches to attempt to design synthetic circuits capable of rhythmicity or predictable behaviors, with the goal of studying the design principles underlying these systems. We are additionally interested in applying some of this knowledge to tackle different biotechnological challenges [Read More].
Our laboratory is in the Department of Molecular Genetics and Microbiology at the School of Biological Sciences, Pontificia Universidad Catolica de Chile, and part of the iBio
Mechanisms of the Neurospora circadian clock
We are interested in the mechanisms underlying the workings of the Neurospora pacemaker, as well as in the different ways in which it regulates rhythmic gene expression [Read More].
We study how light and the circadian clock can impact plant-pathogen interactions [Read more].
Plant cell wall deconstruction
We attempt to characterize the molecular mechanisms through which fungi degrade plant biomass [Read More].
FUNGAL SYNTHETIC BIOLOGY
We study how light responses can be utilized to control gene expression, modifying existing programs or building artificial optogenetic switches [Read More].
We are interested in SynBio approaches to modify and generate circadian oscillators [Read More].
current Funding sources
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