Publications
2024
Larrondo, L. F. Circadian Rhythms: Pervasive, and often times evasive. Philosophical Transactions B. under review
Rojas, V., Rivera, D., Larrondo, L. F. 2024. A new flavor of synthetic yeast communities sees the light. mBio, under review
Goity, A., Dovzhenok, A., Lim, S., Hong, C., Loros, J., Dunlap, J.C., Larrondo, L. F. 2024. Transcriptional rewiring of an evolutionarily conserved circadian clock. EMBO J. doi: 10.1038/s44318-024-00088-3. [Pubmed]
__________
2023
Montenegro-Montero, A., Goity, A., Canessa, P. F., Larrondo, L. F. 2023. Identification of a common secondary mutation in the Neurospora crassa knockout collection conferring a cell fusion-defective phenotype. Mycrobiology Spectrum e0208723. doi: 10.1128/spectrum.02087-23. [Pubmed]
Olivares-Yañez, C., Alesandri, M. P., Salas, L., Larrondo, L. F. 2023. Methylxanthines modulate circadian period length independently of the action of phosphodiesterase. Mycrobiology Spectrum e0372722. doi: 10.1128/spectrum.03727-22. [Pubmed]
Tabilo-Agurto, Del Rio-Pinilla, V., Eltit-Villarroel, V., Goity, A., Muñoz-Guzmán, F., Larrondo, L. F. 2023. Developing a temperature-inducible transcriptional rheostat in Neurospora crassa. mBio. 14(1): e0329122. doi: 10.1128/mBio.03291-22. [Pubmed]
Larrondo, L.F. 2023. Circadian entrainment of in vitro reactions, in real time, and around the clock. Proc Natl Acad Sci U S A. 120(18):e2303566120. doi: 10.1073/pnas.2303566120. [Pubmed]
Pérez-Lara, G., Moyano, T.C., Vega, A., Larrondo, L. F., Polanco, R., Álvarez, J. M., Aguayo, D., Canessa, P. 2023. The Botrytis cinerea Gene Expression Browser. J Fungi (Basel).9(1):84. doi: 10.3390/jof9010084. [Pubmed]
Pérez-Lara, G., Olivares-Yañez, C., Van Bakel, H., Larrondo, L. F., Canessa, P. 2023. Genome-wide characterization of light-regulated gene expression in Botrytis cinerea reveals underlying complex photobiology. Int J Mol Sci. 24(10), 8705; https://doi.org/10.3390/ijms24108705 [Pubmed]
Rojas V. and Larrondo, L. F. 2023. Coupling cell communication and optogenetics: Implementation of a light-inducible intercellular system in yeast. ACS Synth Biol 12(1):71-82. doi:10.1021/acssynbio.2c00338. [Pubmed]
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2022
Henriquez-Urrutia, M., Seguel-Avello, A., Olivares-Yanez, C., Guillén-Alonso, H., Winkler, R., Herrera-Estrella, A., Canessa, P., Larrondo, L. F. 2022. Circadian oscillations in Trichoderma atroviride and the role of core clock components in secondary metabolism, development, and mycoparasitism against the phytopathogen Botrytis cinerea. eLife 11:e71358. doi: 10.7554/eLife.71358. [Pubmed]
Rojas, V., Salinas, F., Romero, A., Larrondo, L. F., Canessa, P. 2022. Interactions between core elements of the Botrytis cinerea circadian clock are modulated by light and different protein domains. Journal of Fungi, 8(5):486. doi: 10.3390/jof8050486. [Pubmed]
Johnson, N. R., Larrondo, L. F., Alvarez, J. M., Vidal, E. A. 2022. Comprehensive re-analysis of hairpin RNAs in fungi reveals ancestral links. eLife 11:e83691. doi: 10.7554/eLife.83691. [Pubmed]
__________
2021
Figueroa, D., Rojas, V., Romero, A., Larrondo, L. F., Salinas, F. 2021. The rise and shine of yeast optogenetics. Yeast. 38 :131-146. [Pubmed]
Zárate R.V., Arancibia, D., Fernández, A., Signorelli, J. R., Larrondo, L. F., Andrés, M. E., Zamorano, P. 2021. Optimization of the Light-On system in a lentiviral platform to a light-controlled expression of genes in neurons. E. J. Biotech. 51, 50-57 [Link]
Munoz-Guzman, F., Caballero, V., Larrondo, L. F. 2021. A Global Search for novel Transcription Factors impacting the Neurospora crassa Circadian Clock. G3. 11, 6 doi.org/10.1093/g3journal/jkab100 [Pubmed]
Romero, A., Rojas, V., Salinas, F., Larrondo, L. F. 2021. Modular and Molecular Optimization of a LOV (Light–Oxygen–Voltage)-Based Optogenetic Switch in Yeast. Int J Mol Sci., 22(16), 8538; doi.org/10.3390/ijms22168538. [Pubmed]
Olivares-Yañez, C., Sánchez, E., Pérez-Lara, G., Seguel, A., Camejo, P., Larrondo, L. F., Vidal, E. A.., Canessa, P. 2021. A comprehensive transcription factor and DNA-binding motif resource for the construction of gene regulatory networks in Botrytis cinerea and Trichoderma atroviride. Comput. Struct. Biotechnol. J. 19:6212–6228 doi: 10.1016/j.csbj.2021.11.012. [Pubmed]
__________
2020
Diaz, R., Larrondo, L. F. 2020. A circadian clock in Neurospora crassa functions during plant cell wall deconstruction. Fungal Biology 124(5):501-508. doi.org/10.1016/j.funbio.2020.03.003 [Pubmed]
Nespolo, R. F., Villarroel, C. A., Oporto, C. I., Tapia, S. M., Vega-Macaya, F., Urbina, K., De Chiara, M., Mozzachiodi, S., Mikhalev, E., Thompson, D., Larrondo, L. F., Saenz-Agudelo, P., Liti, G., Cubillos, F. A. 2020. An Out-of-Patagonia migration explains the worldwide diversity and distribution of Saccharomyces eubayanus lineages. PLoS Genet. May 1;16(5): e1008777. [Pubmed]
Ramos, P., Barrera, A. K., Hereme, RA, Ruiz-Lara, S., Larrondo, L. F., Gundel, P.E., Pollmann, S., Molina-Montenegro, M.A. 2020. Fungal Endophytes Exert Positive Effects on Colobanthus quitensis Under Water Stress but Neutral Under a Projected Climate Change Scenario in Antarctica. Frontiers in Ecology and Evolution, 8. 122 doi.org/10.3389/fmicb.2020.00264 [Pubmed]
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2019
Kessi-Pérez, E. I., Salinas, F., González, A., Su, Y., Guillamón, J. M., Hall, M. N., Larrondo, L. F., Martínez, C. 2019. KAE1 Allelic Variants Affect TORC1 Activation and Fermentation Kinetics in Saccharomyces cerevisiae. Front Microbiol. 10:1686. doi: 10.3389/fmicb.2019.01686. eCollection 2019. [Pubmed]
Crivelente- Horta, M.A., Thieme, N., Gao, Y., Burnum-Johnson, K. E., Nicora, C. D., Gritsenko, M. A., Lipton, M. S., Mohanraj, K., Jose de Assis, L., Lin, L., Tian, C., Braus, G., H., Borkovich, K. A., Schmoll, M., Larrondo, L. F., Samal, A., Goldman, G. H., Benz, P. 2019. Broad substrate-specific phosphorylation events are associated with the initial stage of plant cell wall recognition in Neurospora crassa. Front Microbiol. 10, 2317 [Pubmed]
Larrondo, L. F., Canessa, P. 2019. The clock keeps on ticking: emerging roles for circadian regulation on the control of fungal physiology and pathogenesis. Current Topics in Microbiology and Immunology. doi: 10.1007/82_2018_143. [Pubmed]
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2018
Salinas, F., Rojas, V., Delgado, V., López, J., Agosin, E., Larrondo, L. F. 2018. Fungal Light-Oxygen-Voltage Domains for Optogenetic Control of Gene Expression and Flocculation in Yeast. MBio. 9(4). pii: e00626-18 [Pubmed]
Kessi-Pérez, E.I., Salinas, F., Molinet, J., González, A., Muñiz, S., Guillamón, J.M., Hall, M.N., Larrondo, L. F., Martínez, C. 2018. Indirect monitoring of TORC1 signalling pathway reveals molecular diversity among different yeast strains. Yeast. doi: 10.1002/yea.3351. [Pubmed]
Tapia, S. M., Cuevas, M., Abarca, V., Delgado, V., Rojas, V., García, V., Brice, C., Martínez, C., Salinas, F., Larrondo, L. F., Cubillos, F.A. 2018. GPD1 and ADH3 Natural Variants Underlie Glycerol Yield Differences in Wine Fermentation. Front Microbiol. 3;9:1460. [Pubmed]
Rojas-Aedo, J. F., Gil-Durán, C., Goity, A., Vaca, I., Levicán, G., Larrondo, L. F., Chávez, R. 2018. The developmental regulator Pcz1 affects the production of secondary metabolites in the filamentous fungus Penicillium roqueforti. Microbiol Res. 212-213:67-74. [Pubmed]
Boni, A.C., Ambrósio, D. L., Cupertino, F.B., Montenegro-Montero, A., Virgilio, S., Freitas, F. Z., Corrocher, F.A., Gonçalves, R. D., Yang, A., Weirauch, M.T., Hughes, T. R., Larrondo, L. F., Bertolini, M. C. 2018. Neurospora crassa developmental control mediated by the FLB-3 transcription factor. Fungal Biol. 122:570-582. [Pubmed]
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2017
Franco, D. L. Canessa, P., Bellora, N., Risau-Gusman, S., Olivares-Yañez, C., Pérez-Lara, R., Libkind, D., Larrondo, L. F. Marpegan, L. 2017. Spontaneous circadian rhythms in a cold-adapted natural isolate of Aureobasidium pullulans. Scientific Reports. 7: 13837. doi:10.1038/s41598-017-14085-6 [Pubmed]
Gaskell J, Kersten P, Larrondo LF, Canessa P, Martinez D, Hibbett D, Schmoll M, Kubicek CP, Martinez AT, Yadav J, Master E, Magnuson JK, Yaver D, Berka R, Lail K, Chen C, LaButti K, Nolan M, Lipzen A, Aerts A, Riley R, Barry K, Henrissat B, Blanchette R, Grigoriev IV, Cullen D. 2017. Draft genome sequence of a monokaryotic model brown-rot fungus Postia (Rhodonia) placenta SB12. Genom Data. Aug 10;14:21-23.
doi: 10.1016/j.gdata.2017.08.003 [Pubmed]
Salinas F, Rojas V, Delgado V, Agosin E, Larrondo LF. 2017. Optogenetic switches for light-controlled gene expression in yeast. Appl Microbiol Biotechnol. 101(7):2629-2640.
doi: 10.1007/s00253-017-8178-8 [Pubmed]
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2016
Castillo L, Plaza V, Larrondo LF, Canessa P. 2016. Recent advances in the study of the plant pathogenic fungus Botrytis cinerea and its interaction with the environment. Curr Protein Pept Sci. 2016 Aug 9. [PubMed].
Olivares-Yañez C, Emerson J, Kettenbach A, Loros JJ, Dunlap JC, Larrondo LF. 2016. Modulation of Circadian Gene Expression and Metabolic Compensation by the RCO-1 Corepressor of Neurospora crassa. Genetics. Sep;204(1):163-76. doi: 10.1534/genetics.116.191064. [PubMed] [PDF] [Article Altmetrics].
Feeney KA, Hansen LL, Putker M, Olivares-Yañez C, Day J, Eades LJ, Larrondo LF, Hoyle NP, O'Neill JS, van Ooijen G. 2016. Daily magnesium fluxes regulate cellular timekeeping and energy balance. Nature. 2016 Apr 21;532(7599):375-9. doi: 10.1038/nature17407. [Pubmed] [PDF] [Article Altmetrics].
Hevia MA, Canessa P, Larrondo LF. 2016. Circadian clocks and the regulation of virulence in fungi: Getting up to speed. Semin Cell Dev Biol. Sep;57:147-55. doi: 10.1016/j.semcdb.2016.03.021. [PubMed] [PDF] [Article Altmetrics].
Kessi-Pérez EI, Araos S, García V, Salinas F, Abarca V, Larrondo LF, Martínez C, Cubillos FA. 2016. RIM15 antagonistic pleiotropy is responsible for differences in fermentation and stress response kinetics in budding yeast. FEMS Yeast Res. May;16(3). pii: fow021. doi: 10.1093/femsyr/fow021. [PubMed] [PDF] [Article Altmetrics].
Salinas F, de Boer CG, Abarca V, García V, Cuevas M, Araos S, Larrondo LF, Martínez C, Cubillos FA. 2016. Natural variation in non-coding regions underlying phenotypic diversity in budding yeast. Sci Rep. Feb 22;6:21849.
doi: 10.1038/srep21849. [PubMed] [PDF] [Article Altmetrics].
Montenegro-Montero A, Larrondo LF. 2016. In the Driver's Seat: The Case for Transcriptional Regulation and Coupling as Relevant Determinants of the Circadian Transcriptome and Proteome in Eukaryotes. J Biol Rhythms. Feb;31(1):37-47. doi: 10.1177/0748730415607321. [PubMed] [PDF] [Article Altmetrics].
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2015
Montenegro-Montero A, Canessa P, Larrondo LF. 2015. Around the Fungal Clock: Recent Advances in the Molecular Study of Circadian Clocks in Neurospora and Other Fungi. Adv Genet. 92:107-84.
doi: 10.1016/bs.adgen.2015.09.003. [PubMed] [PDF] [Article Altmetrics].
Montenegro-Montero A, Goity A, Larrondo LF. 2015. The bZIP Transcription Factor HAC-1 Is Involved in the Unfolded Protein Response and Is Necessary for Growth on Cellulose in Neurospora crassa. PLoS One. 2015 Jul 1;10(7):e0131415. doi: 10.1371/journal.pone.0131415. [PubMed] [PDF] [Article Altmetrics].
Hevia MA, Canessa P, Müller-Esparza H, Larrondo LF. 2015. A circadian oscillator in the fungus Botrytis cinerea regulates virulence when infecting Arabidopsis thaliana. Proc Natl Acad Sci U S A. Jul 14;112(28):8744-9. doi: 10.1073/pnas.1508432112. [PubMed] [PDF] [Article Altmetrics].
Plaza V, Lagües Y, Carvajal M, Pérez-García LA, Mora-Montes HM, Canessa P, Larrondo LF, Castillo L. 2015. bcpmr1 encodes a P-type Ca(2+)/Mn(2+)-ATPase mediating cell-wall integrity and virulence in the phytopathogen Botrytis cinerea. Fungal Genet Biol. Mar;76:36-46. doi: 10.1016/j.fgb.2015.01.012. [PubMed] [PDF] [Article Altmetrics].
Larrondo LF, Olivares-Yañez C, Baker CL, Loros JJ, Dunlap JC. 2015. Circadian rhythms. Decoupling circadian clock protein turnover from circadian period determination. Science. Jan 30;347(6221):1257277. doi: 10.1126/science.1257277. [PubMed] [PDF] [Article Altmetrics].
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2014
Hori C, Ishida T, Igarashi K, Samejima M, Suzuki H, Master E, Ferreira P, Ruiz-Dueñas FJ, Held B, Canessa P, Larrondo LF, Schmoll M, Druzhinina IS, Kubicek CP, Gaskell JA, Kersten P, St John F, Glasner J, Sabat G, Splinter BonDurant S, Syed K, Yadav J, Mgbeahuruike AC, Kovalchuk A, Asiegbu FO, Lackner G, Hoffmeister D, Rencoret J, Gutiérrez A, Sun H, Lindquist E, Barry K, Riley R, Grigoriev IV, Henrissat B, Kües U, Berka RM, Martínez AT, Covert SF, Blanchette RA, Cullen D. 2014. Analysis of the Phlebiopsis gigantea genome, transcriptome and secretome provides insight into its pioneer colonization strategies of wood. PLoS Genet. Dec 4;10(12):e1004759.
doi: 10.1371/journal.pgen.1004759. [PubMed] [PDF] [Article Altmetrics].
Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, Walhout AJ, Bouget FY, Ratsch G, Larrondo LF, Ecker JR, Hughes TR. 2014. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. Sep 11;158(6):1431-43. doi:10.1016/j.cell.2014.08.009. [PubMed] [PDF] [Article Altmetrics].
Gooch VD, Johnson AE, Larrondo LF, Loros JJ, Dunlap JC. 2014. Bright to dim oscillatory response of the Neurospora circadian oscillator. J Biol Rhythms. Feb;29(1):49-59. doi: 10.1177/0748730413517983. [PubMed] [PDF] [Article Altmetrics].
Gooch VD, Johnson AE, Bourne BJ, Nix BT, Maas JA, Fox JA, Loros JJ, Larrondo LF, Dunlap JC. 2014. A kinetic study of the effects of light on circadian rhythmicity of the frq promoter of Neurospora crassa. J Biol Rhythms. Feb;29(1):38-48. doi: 10.1177/0748730413517981. [PubMed] [PDF] [Article Altmetrics].
Hong CI, Zámborszky J, Baek M, Labiscsak L, Ju K, Lee H, Larrondo LF, Goity A, Chong HS, Belden WJ, Csikász-Nagy A. 2014. Circadian rhythms synchronize mitosis in Neurospora crassa. Proc Natl Acad Sci U S A. Jan 28;111(4):1397-402. doi: 10.1073/pnas.1319399111. [PubMed] [PDF] [Article Altmetrics].
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2013
Canessa P, Schumacher J, Hevia MA, Tudzynski P, Larrondo LF. 2013. Assessing the effects of light on differentiation and virulence of the plant pathogen Botrytis cinerea: characterization of the White Collar Complex. PLoS One. Dec 31;8(12):e84223. doi: 10.1371/journal.pone.0084223. [PubMed] [PDF] [Article Altmetrics].
Hurley JM, Larrondo LF, Loros JJ, Dunlap JC. 2013. Conserved RNA helicase FRH acts nonenzymatically to support the intrinsically disordered neurospora clock protein FRQ. Mol Cell. Dec 26;52(6):832-43.
doi: 10.1016/j.molcel.2013.11.005.
[PubMed] [PDF] [Article Altmetrics].
Canessa P, Larrondo LF. 2013. Environmental responses and the control of iron homeostasis in fungal systems. Appl Microbiol Biotechnol. Feb;97(3):939-55. doi: 10.1007/s00253-012-4615-x. [PubMed] [PDF] [Article Altmetrics].
Montenegro-Montero A, Larrondo LF. 2013. The Neurospora Circadian System: From Genes to Proteins and Back, in Less Than 24 Hours. In "Neurospora Genomics and Molecular Biology", Edited by McCluskey, K. and Kasbekar, D.P., pp. 243-271
[Book Website] [PDF].
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2012
Floudas D, Binder M, Riley R, Barry K, Blanchette RA, Henrissat B, Martínez AT, Otillar R, Spatafora JW, Yadav JS, Aerts A, Benoit I, Boyd A, Carlson A, Copeland A, Coutinho PM, de Vries RP, Ferreira P, Findley K, Foster B, Gaskell J, Glotzer D, Górecki P, Heitman J, Hesse C, Hori C, Igarashi K, Jurgens JA, Kallen N, Kersten P, Kohler A, Kües U, Kumar TK, Kuo A, LaButti K, Larrondo LF, Lindquist E, Ling A, Lombard V, Lucas S, Lundell T, Martin R, McLaughlin DJ, Morgenstern I, Morin E, Murat C, Nagy LG, Nolan M, Ohm RA, Patyshakuliyeva A, Rokas A, Ruiz-Dueñas FJ, Sabat G, Salamov A, Samejima M, Schmutz J, Slot JC, St John F, Stenlid J, Sun H, Sun S, Syed K, Tsang A, Wiebenga A, Young D, Pisabarro A, Eastwood DC, Martin F, Cullen D, Grigoriev IV, Hibbett DS. 2012. The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes. Science. Jun 29;336(6089):1715-9.
doi: 10.1126/science.1221748. [PubMed] [PDF] [Article Altmetrics].
Canessa P, Muñoz-Guzmán F, Vicuña R, Larrondo LF. 2012. Characterization of PIR1, a GATA family transcription factor involved in iron responses in the white-rot fungus Phanerochaete chrysosporium. Fungal Genet Biol. Aug;49(8):626-34.
doi: 10.1016/j.fgb.2012.05.013.
[PubMed] [PDF] [Article Altmetrics].
Larrondo LF, Loros JJ, Dunlap JC. 2012. High-resolution spatiotemporal analysis of gene expression in real time: in vivo analysis of circadian rhythms in Neurospora crassa using a FREQUENCY-luciferase translational reporter. Fungal Genet Biol. Sep;49(9):681-3. doi: 10.1016/j.fgb.2012.06.001. [PubMed] [PDF] [Article Altmetrics].
Fernandez-Fueyo E, Ruiz-Dueñas FJ, Ferreira P, Floudas D, Hibbett DS, Canessa P, Larrondo LF, James TY, Seelenfreund D, Lobos S, Polanco R, Tello M, Honda Y, Watanabe T, Watanabe T, Ryu JS, Kubicek CP, Schmoll M, Gaskell J, Hammel KE, St John FJ, Vanden Wymelenberg A, Sabat G, Splinter BonDurant S, Syed K, Yadav JS, Doddapaneni H, Subramanian V, Lavín JL, Oguiza JA, Perez G, Pisabarro AG, Ramirez L, Santoyo F, Master E, Coutinho PM, Henrissat B, Lombard V, Magnuson JK, Kües U, Hori C, Igarashi K, Samejima M, Held BW, Barry KW, LaButti KM, Lapidus A, Lindquist EA, Lucas SM, Riley R, Salamov AA, Hoffmeister D, Schwenk D, Hadar Y, Yarden O, de Vries RP, Wiebenga A, Stenlid J, Eastwood D, Grigoriev IV, Berka RM, Blanchette RA, Kersten P, Martinez AT, Vicuna R, Cullen D. 2012. Comparative genomics of Ceriporiopsis subvermispora and Phanerochaete chrysosporium provide insight into selective ligninolysis. Proc Natl Acad Sci U S A. Apr 3;109(14):5458-63.
doi: 10.1073/pnas.1119912109. [PubMed] [PDF] [Article Altmetrics].
For a full list of publications, see here
Larrondo, L. F. Circadian Rhythms: Pervasive, and often times evasive. Philosophical Transactions B. under review
Rojas, V., Rivera, D., Larrondo, L. F. 2024. A new flavor of synthetic yeast communities sees the light. mBio, under review
Goity, A., Dovzhenok, A., Lim, S., Hong, C., Loros, J., Dunlap, J.C., Larrondo, L. F. 2024. Transcriptional rewiring of an evolutionarily conserved circadian clock. EMBO J. doi: 10.1038/s44318-024-00088-3. [Pubmed]
__________
2023
Montenegro-Montero, A., Goity, A., Canessa, P. F., Larrondo, L. F. 2023. Identification of a common secondary mutation in the Neurospora crassa knockout collection conferring a cell fusion-defective phenotype. Mycrobiology Spectrum e0208723. doi: 10.1128/spectrum.02087-23. [Pubmed]
Olivares-Yañez, C., Alesandri, M. P., Salas, L., Larrondo, L. F. 2023. Methylxanthines modulate circadian period length independently of the action of phosphodiesterase. Mycrobiology Spectrum e0372722. doi: 10.1128/spectrum.03727-22. [Pubmed]
Tabilo-Agurto, Del Rio-Pinilla, V., Eltit-Villarroel, V., Goity, A., Muñoz-Guzmán, F., Larrondo, L. F. 2023. Developing a temperature-inducible transcriptional rheostat in Neurospora crassa. mBio. 14(1): e0329122. doi: 10.1128/mBio.03291-22. [Pubmed]
Larrondo, L.F. 2023. Circadian entrainment of in vitro reactions, in real time, and around the clock. Proc Natl Acad Sci U S A. 120(18):e2303566120. doi: 10.1073/pnas.2303566120. [Pubmed]
Pérez-Lara, G., Moyano, T.C., Vega, A., Larrondo, L. F., Polanco, R., Álvarez, J. M., Aguayo, D., Canessa, P. 2023. The Botrytis cinerea Gene Expression Browser. J Fungi (Basel).9(1):84. doi: 10.3390/jof9010084. [Pubmed]
Pérez-Lara, G., Olivares-Yañez, C., Van Bakel, H., Larrondo, L. F., Canessa, P. 2023. Genome-wide characterization of light-regulated gene expression in Botrytis cinerea reveals underlying complex photobiology. Int J Mol Sci. 24(10), 8705; https://doi.org/10.3390/ijms24108705 [Pubmed]
Rojas V. and Larrondo, L. F. 2023. Coupling cell communication and optogenetics: Implementation of a light-inducible intercellular system in yeast. ACS Synth Biol 12(1):71-82. doi:10.1021/acssynbio.2c00338. [Pubmed]
__________
2022
Henriquez-Urrutia, M., Seguel-Avello, A., Olivares-Yanez, C., Guillén-Alonso, H., Winkler, R., Herrera-Estrella, A., Canessa, P., Larrondo, L. F. 2022. Circadian oscillations in Trichoderma atroviride and the role of core clock components in secondary metabolism, development, and mycoparasitism against the phytopathogen Botrytis cinerea. eLife 11:e71358. doi: 10.7554/eLife.71358. [Pubmed]
Rojas, V., Salinas, F., Romero, A., Larrondo, L. F., Canessa, P. 2022. Interactions between core elements of the Botrytis cinerea circadian clock are modulated by light and different protein domains. Journal of Fungi, 8(5):486. doi: 10.3390/jof8050486. [Pubmed]
Johnson, N. R., Larrondo, L. F., Alvarez, J. M., Vidal, E. A. 2022. Comprehensive re-analysis of hairpin RNAs in fungi reveals ancestral links. eLife 11:e83691. doi: 10.7554/eLife.83691. [Pubmed]
__________
2021
Figueroa, D., Rojas, V., Romero, A., Larrondo, L. F., Salinas, F. 2021. The rise and shine of yeast optogenetics. Yeast. 38 :131-146. [Pubmed]
Zárate R.V., Arancibia, D., Fernández, A., Signorelli, J. R., Larrondo, L. F., Andrés, M. E., Zamorano, P. 2021. Optimization of the Light-On system in a lentiviral platform to a light-controlled expression of genes in neurons. E. J. Biotech. 51, 50-57 [Link]
Munoz-Guzman, F., Caballero, V., Larrondo, L. F. 2021. A Global Search for novel Transcription Factors impacting the Neurospora crassa Circadian Clock. G3. 11, 6 doi.org/10.1093/g3journal/jkab100 [Pubmed]
Romero, A., Rojas, V., Salinas, F., Larrondo, L. F. 2021. Modular and Molecular Optimization of a LOV (Light–Oxygen–Voltage)-Based Optogenetic Switch in Yeast. Int J Mol Sci., 22(16), 8538; doi.org/10.3390/ijms22168538. [Pubmed]
Olivares-Yañez, C., Sánchez, E., Pérez-Lara, G., Seguel, A., Camejo, P., Larrondo, L. F., Vidal, E. A.., Canessa, P. 2021. A comprehensive transcription factor and DNA-binding motif resource for the construction of gene regulatory networks in Botrytis cinerea and Trichoderma atroviride. Comput. Struct. Biotechnol. J. 19:6212–6228 doi: 10.1016/j.csbj.2021.11.012. [Pubmed]
__________
2020
Diaz, R., Larrondo, L. F. 2020. A circadian clock in Neurospora crassa functions during plant cell wall deconstruction. Fungal Biology 124(5):501-508. doi.org/10.1016/j.funbio.2020.03.003 [Pubmed]
Nespolo, R. F., Villarroel, C. A., Oporto, C. I., Tapia, S. M., Vega-Macaya, F., Urbina, K., De Chiara, M., Mozzachiodi, S., Mikhalev, E., Thompson, D., Larrondo, L. F., Saenz-Agudelo, P., Liti, G., Cubillos, F. A. 2020. An Out-of-Patagonia migration explains the worldwide diversity and distribution of Saccharomyces eubayanus lineages. PLoS Genet. May 1;16(5): e1008777. [Pubmed]
Ramos, P., Barrera, A. K., Hereme, RA, Ruiz-Lara, S., Larrondo, L. F., Gundel, P.E., Pollmann, S., Molina-Montenegro, M.A. 2020. Fungal Endophytes Exert Positive Effects on Colobanthus quitensis Under Water Stress but Neutral Under a Projected Climate Change Scenario in Antarctica. Frontiers in Ecology and Evolution, 8. 122 doi.org/10.3389/fmicb.2020.00264 [Pubmed]
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2019
Kessi-Pérez, E. I., Salinas, F., González, A., Su, Y., Guillamón, J. M., Hall, M. N., Larrondo, L. F., Martínez, C. 2019. KAE1 Allelic Variants Affect TORC1 Activation and Fermentation Kinetics in Saccharomyces cerevisiae. Front Microbiol. 10:1686. doi: 10.3389/fmicb.2019.01686. eCollection 2019. [Pubmed]
Crivelente- Horta, M.A., Thieme, N., Gao, Y., Burnum-Johnson, K. E., Nicora, C. D., Gritsenko, M. A., Lipton, M. S., Mohanraj, K., Jose de Assis, L., Lin, L., Tian, C., Braus, G., H., Borkovich, K. A., Schmoll, M., Larrondo, L. F., Samal, A., Goldman, G. H., Benz, P. 2019. Broad substrate-specific phosphorylation events are associated with the initial stage of plant cell wall recognition in Neurospora crassa. Front Microbiol. 10, 2317 [Pubmed]
Larrondo, L. F., Canessa, P. 2019. The clock keeps on ticking: emerging roles for circadian regulation on the control of fungal physiology and pathogenesis. Current Topics in Microbiology and Immunology. doi: 10.1007/82_2018_143. [Pubmed]
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2018
Salinas, F., Rojas, V., Delgado, V., López, J., Agosin, E., Larrondo, L. F. 2018. Fungal Light-Oxygen-Voltage Domains for Optogenetic Control of Gene Expression and Flocculation in Yeast. MBio. 9(4). pii: e00626-18 [Pubmed]
Kessi-Pérez, E.I., Salinas, F., Molinet, J., González, A., Muñiz, S., Guillamón, J.M., Hall, M.N., Larrondo, L. F., Martínez, C. 2018. Indirect monitoring of TORC1 signalling pathway reveals molecular diversity among different yeast strains. Yeast. doi: 10.1002/yea.3351. [Pubmed]
Tapia, S. M., Cuevas, M., Abarca, V., Delgado, V., Rojas, V., García, V., Brice, C., Martínez, C., Salinas, F., Larrondo, L. F., Cubillos, F.A. 2018. GPD1 and ADH3 Natural Variants Underlie Glycerol Yield Differences in Wine Fermentation. Front Microbiol. 3;9:1460. [Pubmed]
Rojas-Aedo, J. F., Gil-Durán, C., Goity, A., Vaca, I., Levicán, G., Larrondo, L. F., Chávez, R. 2018. The developmental regulator Pcz1 affects the production of secondary metabolites in the filamentous fungus Penicillium roqueforti. Microbiol Res. 212-213:67-74. [Pubmed]
Boni, A.C., Ambrósio, D. L., Cupertino, F.B., Montenegro-Montero, A., Virgilio, S., Freitas, F. Z., Corrocher, F.A., Gonçalves, R. D., Yang, A., Weirauch, M.T., Hughes, T. R., Larrondo, L. F., Bertolini, M. C. 2018. Neurospora crassa developmental control mediated by the FLB-3 transcription factor. Fungal Biol. 122:570-582. [Pubmed]
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2017
Franco, D. L. Canessa, P., Bellora, N., Risau-Gusman, S., Olivares-Yañez, C., Pérez-Lara, R., Libkind, D., Larrondo, L. F. Marpegan, L. 2017. Spontaneous circadian rhythms in a cold-adapted natural isolate of Aureobasidium pullulans. Scientific Reports. 7: 13837. doi:10.1038/s41598-017-14085-6 [Pubmed]
Gaskell J, Kersten P, Larrondo LF, Canessa P, Martinez D, Hibbett D, Schmoll M, Kubicek CP, Martinez AT, Yadav J, Master E, Magnuson JK, Yaver D, Berka R, Lail K, Chen C, LaButti K, Nolan M, Lipzen A, Aerts A, Riley R, Barry K, Henrissat B, Blanchette R, Grigoriev IV, Cullen D. 2017. Draft genome sequence of a monokaryotic model brown-rot fungus Postia (Rhodonia) placenta SB12. Genom Data. Aug 10;14:21-23.
doi: 10.1016/j.gdata.2017.08.003 [Pubmed]
Salinas F, Rojas V, Delgado V, Agosin E, Larrondo LF. 2017. Optogenetic switches for light-controlled gene expression in yeast. Appl Microbiol Biotechnol. 101(7):2629-2640.
doi: 10.1007/s00253-017-8178-8 [Pubmed]
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2016
Castillo L, Plaza V, Larrondo LF, Canessa P. 2016. Recent advances in the study of the plant pathogenic fungus Botrytis cinerea and its interaction with the environment. Curr Protein Pept Sci. 2016 Aug 9. [PubMed].
Olivares-Yañez C, Emerson J, Kettenbach A, Loros JJ, Dunlap JC, Larrondo LF. 2016. Modulation of Circadian Gene Expression and Metabolic Compensation by the RCO-1 Corepressor of Neurospora crassa. Genetics. Sep;204(1):163-76. doi: 10.1534/genetics.116.191064. [PubMed] [PDF] [Article Altmetrics].
Feeney KA, Hansen LL, Putker M, Olivares-Yañez C, Day J, Eades LJ, Larrondo LF, Hoyle NP, O'Neill JS, van Ooijen G. 2016. Daily magnesium fluxes regulate cellular timekeeping and energy balance. Nature. 2016 Apr 21;532(7599):375-9. doi: 10.1038/nature17407. [Pubmed] [PDF] [Article Altmetrics].
Hevia MA, Canessa P, Larrondo LF. 2016. Circadian clocks and the regulation of virulence in fungi: Getting up to speed. Semin Cell Dev Biol. Sep;57:147-55. doi: 10.1016/j.semcdb.2016.03.021. [PubMed] [PDF] [Article Altmetrics].
Kessi-Pérez EI, Araos S, García V, Salinas F, Abarca V, Larrondo LF, Martínez C, Cubillos FA. 2016. RIM15 antagonistic pleiotropy is responsible for differences in fermentation and stress response kinetics in budding yeast. FEMS Yeast Res. May;16(3). pii: fow021. doi: 10.1093/femsyr/fow021. [PubMed] [PDF] [Article Altmetrics].
Salinas F, de Boer CG, Abarca V, García V, Cuevas M, Araos S, Larrondo LF, Martínez C, Cubillos FA. 2016. Natural variation in non-coding regions underlying phenotypic diversity in budding yeast. Sci Rep. Feb 22;6:21849.
doi: 10.1038/srep21849. [PubMed] [PDF] [Article Altmetrics].
Montenegro-Montero A, Larrondo LF. 2016. In the Driver's Seat: The Case for Transcriptional Regulation and Coupling as Relevant Determinants of the Circadian Transcriptome and Proteome in Eukaryotes. J Biol Rhythms. Feb;31(1):37-47. doi: 10.1177/0748730415607321. [PubMed] [PDF] [Article Altmetrics].
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2015
Montenegro-Montero A, Canessa P, Larrondo LF. 2015. Around the Fungal Clock: Recent Advances in the Molecular Study of Circadian Clocks in Neurospora and Other Fungi. Adv Genet. 92:107-84.
doi: 10.1016/bs.adgen.2015.09.003. [PubMed] [PDF] [Article Altmetrics].
Montenegro-Montero A, Goity A, Larrondo LF. 2015. The bZIP Transcription Factor HAC-1 Is Involved in the Unfolded Protein Response and Is Necessary for Growth on Cellulose in Neurospora crassa. PLoS One. 2015 Jul 1;10(7):e0131415. doi: 10.1371/journal.pone.0131415. [PubMed] [PDF] [Article Altmetrics].
Hevia MA, Canessa P, Müller-Esparza H, Larrondo LF. 2015. A circadian oscillator in the fungus Botrytis cinerea regulates virulence when infecting Arabidopsis thaliana. Proc Natl Acad Sci U S A. Jul 14;112(28):8744-9. doi: 10.1073/pnas.1508432112. [PubMed] [PDF] [Article Altmetrics].
Plaza V, Lagües Y, Carvajal M, Pérez-García LA, Mora-Montes HM, Canessa P, Larrondo LF, Castillo L. 2015. bcpmr1 encodes a P-type Ca(2+)/Mn(2+)-ATPase mediating cell-wall integrity and virulence in the phytopathogen Botrytis cinerea. Fungal Genet Biol. Mar;76:36-46. doi: 10.1016/j.fgb.2015.01.012. [PubMed] [PDF] [Article Altmetrics].
Larrondo LF, Olivares-Yañez C, Baker CL, Loros JJ, Dunlap JC. 2015. Circadian rhythms. Decoupling circadian clock protein turnover from circadian period determination. Science. Jan 30;347(6221):1257277. doi: 10.1126/science.1257277. [PubMed] [PDF] [Article Altmetrics].
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2014
Hori C, Ishida T, Igarashi K, Samejima M, Suzuki H, Master E, Ferreira P, Ruiz-Dueñas FJ, Held B, Canessa P, Larrondo LF, Schmoll M, Druzhinina IS, Kubicek CP, Gaskell JA, Kersten P, St John F, Glasner J, Sabat G, Splinter BonDurant S, Syed K, Yadav J, Mgbeahuruike AC, Kovalchuk A, Asiegbu FO, Lackner G, Hoffmeister D, Rencoret J, Gutiérrez A, Sun H, Lindquist E, Barry K, Riley R, Grigoriev IV, Henrissat B, Kües U, Berka RM, Martínez AT, Covert SF, Blanchette RA, Cullen D. 2014. Analysis of the Phlebiopsis gigantea genome, transcriptome and secretome provides insight into its pioneer colonization strategies of wood. PLoS Genet. Dec 4;10(12):e1004759.
doi: 10.1371/journal.pgen.1004759. [PubMed] [PDF] [Article Altmetrics].
Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, Walhout AJ, Bouget FY, Ratsch G, Larrondo LF, Ecker JR, Hughes TR. 2014. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. Sep 11;158(6):1431-43. doi:10.1016/j.cell.2014.08.009. [PubMed] [PDF] [Article Altmetrics].
Gooch VD, Johnson AE, Larrondo LF, Loros JJ, Dunlap JC. 2014. Bright to dim oscillatory response of the Neurospora circadian oscillator. J Biol Rhythms. Feb;29(1):49-59. doi: 10.1177/0748730413517983. [PubMed] [PDF] [Article Altmetrics].
Gooch VD, Johnson AE, Bourne BJ, Nix BT, Maas JA, Fox JA, Loros JJ, Larrondo LF, Dunlap JC. 2014. A kinetic study of the effects of light on circadian rhythmicity of the frq promoter of Neurospora crassa. J Biol Rhythms. Feb;29(1):38-48. doi: 10.1177/0748730413517981. [PubMed] [PDF] [Article Altmetrics].
Hong CI, Zámborszky J, Baek M, Labiscsak L, Ju K, Lee H, Larrondo LF, Goity A, Chong HS, Belden WJ, Csikász-Nagy A. 2014. Circadian rhythms synchronize mitosis in Neurospora crassa. Proc Natl Acad Sci U S A. Jan 28;111(4):1397-402. doi: 10.1073/pnas.1319399111. [PubMed] [PDF] [Article Altmetrics].
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2013
Canessa P, Schumacher J, Hevia MA, Tudzynski P, Larrondo LF. 2013. Assessing the effects of light on differentiation and virulence of the plant pathogen Botrytis cinerea: characterization of the White Collar Complex. PLoS One. Dec 31;8(12):e84223. doi: 10.1371/journal.pone.0084223. [PubMed] [PDF] [Article Altmetrics].
Hurley JM, Larrondo LF, Loros JJ, Dunlap JC. 2013. Conserved RNA helicase FRH acts nonenzymatically to support the intrinsically disordered neurospora clock protein FRQ. Mol Cell. Dec 26;52(6):832-43.
doi: 10.1016/j.molcel.2013.11.005.
[PubMed] [PDF] [Article Altmetrics].
Canessa P, Larrondo LF. 2013. Environmental responses and the control of iron homeostasis in fungal systems. Appl Microbiol Biotechnol. Feb;97(3):939-55. doi: 10.1007/s00253-012-4615-x. [PubMed] [PDF] [Article Altmetrics].
Montenegro-Montero A, Larrondo LF. 2013. The Neurospora Circadian System: From Genes to Proteins and Back, in Less Than 24 Hours. In "Neurospora Genomics and Molecular Biology", Edited by McCluskey, K. and Kasbekar, D.P., pp. 243-271
[Book Website] [PDF].
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2012
Floudas D, Binder M, Riley R, Barry K, Blanchette RA, Henrissat B, Martínez AT, Otillar R, Spatafora JW, Yadav JS, Aerts A, Benoit I, Boyd A, Carlson A, Copeland A, Coutinho PM, de Vries RP, Ferreira P, Findley K, Foster B, Gaskell J, Glotzer D, Górecki P, Heitman J, Hesse C, Hori C, Igarashi K, Jurgens JA, Kallen N, Kersten P, Kohler A, Kües U, Kumar TK, Kuo A, LaButti K, Larrondo LF, Lindquist E, Ling A, Lombard V, Lucas S, Lundell T, Martin R, McLaughlin DJ, Morgenstern I, Morin E, Murat C, Nagy LG, Nolan M, Ohm RA, Patyshakuliyeva A, Rokas A, Ruiz-Dueñas FJ, Sabat G, Salamov A, Samejima M, Schmutz J, Slot JC, St John F, Stenlid J, Sun H, Sun S, Syed K, Tsang A, Wiebenga A, Young D, Pisabarro A, Eastwood DC, Martin F, Cullen D, Grigoriev IV, Hibbett DS. 2012. The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes. Science. Jun 29;336(6089):1715-9.
doi: 10.1126/science.1221748. [PubMed] [PDF] [Article Altmetrics].
Canessa P, Muñoz-Guzmán F, Vicuña R, Larrondo LF. 2012. Characterization of PIR1, a GATA family transcription factor involved in iron responses in the white-rot fungus Phanerochaete chrysosporium. Fungal Genet Biol. Aug;49(8):626-34.
doi: 10.1016/j.fgb.2012.05.013.
[PubMed] [PDF] [Article Altmetrics].
Larrondo LF, Loros JJ, Dunlap JC. 2012. High-resolution spatiotemporal analysis of gene expression in real time: in vivo analysis of circadian rhythms in Neurospora crassa using a FREQUENCY-luciferase translational reporter. Fungal Genet Biol. Sep;49(9):681-3. doi: 10.1016/j.fgb.2012.06.001. [PubMed] [PDF] [Article Altmetrics].
Fernandez-Fueyo E, Ruiz-Dueñas FJ, Ferreira P, Floudas D, Hibbett DS, Canessa P, Larrondo LF, James TY, Seelenfreund D, Lobos S, Polanco R, Tello M, Honda Y, Watanabe T, Watanabe T, Ryu JS, Kubicek CP, Schmoll M, Gaskell J, Hammel KE, St John FJ, Vanden Wymelenberg A, Sabat G, Splinter BonDurant S, Syed K, Yadav JS, Doddapaneni H, Subramanian V, Lavín JL, Oguiza JA, Perez G, Pisabarro AG, Ramirez L, Santoyo F, Master E, Coutinho PM, Henrissat B, Lombard V, Magnuson JK, Kües U, Hori C, Igarashi K, Samejima M, Held BW, Barry KW, LaButti KM, Lapidus A, Lindquist EA, Lucas SM, Riley R, Salamov AA, Hoffmeister D, Schwenk D, Hadar Y, Yarden O, de Vries RP, Wiebenga A, Stenlid J, Eastwood D, Grigoriev IV, Berka RM, Blanchette RA, Kersten P, Martinez AT, Vicuna R, Cullen D. 2012. Comparative genomics of Ceriporiopsis subvermispora and Phanerochaete chrysosporium provide insight into selective ligninolysis. Proc Natl Acad Sci U S A. Apr 3;109(14):5458-63.
doi: 10.1073/pnas.1119912109. [PubMed] [PDF] [Article Altmetrics].
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